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High-Definition Field of Vision on Imaging

"I was confirmed in stage 4 lymphoma by my initial visit to hospital. Dr. Tang comforted me that there is no need to be too nervous -- in fact stage 4 lymphoma is not advanced cancer and it is very likely to heal" read in the book Death to Life from Li Kaifu. When he realized that his life was "staged" but he decided to embrace the world anyway.

The TNM staging system is currently the most widely used staging system in the world. It can provide relevant information about the location, involvement and spread of the primary tumor through imagological examination methods. It's one of the most important examination methods to determine cancer staging. Integrated PET/MR perfectly combines molecular functions and structural images and serves as a vital means for the clinical diagnosis of tumors, cardiovascular disease, neurological disease, pediatric disease, and inflammatory disease.

However, since the launch of integrated PET/MR more than ten years ago, there have been limitations on scan efficiency. The short AFOV of PET fails to meet the needs of whole-body imaging, so it's been necessary to scan patients over multiple bed positions, which increases the scan time and reduces patient throughput.

Stages of Life under Super Wide Angle
Stages of Life under Super Wide Angle

Compared with the conventional PET system with AFOV ranging between 20cm and 25cm, the 32cm long AFOV not only improves the sensitivity of the system, but also basically covers main organs of the whole body and the regional lymphatic system where metastasis may occur, and makes it possible to realize cancer TN staging in one bed position.

Traditionally, a PET/MR scan of a tumor patient takes about 35 to 50 minutes. The long AFOV can further optimize the PET/MR tumor scanning scheme. In other words, it can optimize the decision about whether to scan the whole body based on whether the tumor patient has regional lymphatic metastasis after regional PET/MR scan, potentially saving scan time for patients without metastasis.

In August 2019, Peking Cancer Hospital introduced United Imaging Healthcare's integrated PET/MR to make an in-depth exploration and optimization of cancer TNM staging under long AFOV. More than 500 examples of scanning various organs proved that long AFOV PET/MR could greatly increase the scan range over one bed position and improve the efficiency of cancer TNM staging.

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Clinical Cases
The following are the cases of optimized TNM staging of breast cancer, esophageal cancer, prostate cancer and other diseases under the long axial field of "spatio-temporal integration" ULTRA-clear TOF PET/MR.  Thanks to Capital Medical University Xuanwu Medical Treatment for providing the image.
Stages of Life under Super Wide Angle
Breast Cancer
Regional long AFOV PET/MR high-resolution scan of breast: 15 minutes
As can be seen from the above picture, the long AFOV PET scan of breast over one bed position can cover breast tissue and axillary tissue and give a comprehensive assessment of the primary tumor and axillary metastases. The PET images have a high signal-to-noise ratio and show the lesion clearly. Together with different MR sequences, the doctor can easily locate the lesion, assess the extent of the lesion and its relationship with surrounding tissues, and provide more information for subsequent puncture or surgery. 
 
Stages of Life under Super Wide Angle
Prostate Pancer
Single-bed Long-axis View PET/MR Localised High-resolution Scan of The Prostate
The image above shows bone metastases in the pelvic cavity on single-bed scan, followed by whole-body scan, showing systemic bone metastases. 
 
 
 
 
 
 
Stages of Life under Super Wide Angle
Esophageal Cancer
Regional long AFOV PET/MR high-resolution scan of esophagus over one bed position: cardiac, middle esophagus, upper esophagus
As shown in the picture, the long AFOV PET/MR scan over one bed position can cover the entire esophagus, making it possible to diagnose and assess esophageal cancer in different parts. Besides, the long AFOV PET/MR scan provides enough scan time, delivers PET images with high signal-to-noise ratio and shows the lesion clearly. Together with different MR sequences, it can decide esophageal cancer staging precisely. 
 
 
Stages of Life under Super Wide Angle
Pancreatic Neuroendocrine Tumours
Regional long AFOV PET/MR high-resolution scan of pancreas over one bed position
As can be seen from the above picture, the pancreatic neuroendocrine tumors originate in peptidergic neurons and pancreatic neuroendocrine cells, accounting for 1.3% to 10% of all pancreatic tumors. Although it's relatively indolent compared with pancreatic cancer, 20% to 64% of patients pancreatic neuroendocrine tumors have distant metastases at the time of diagnosis, of which liver metastases are the most common. Compared with the conventional short AFOV PET/MR, the 32cm long AFOV PET/MR can fully cover liver organs and assess liver metastases of pancreatic neuroendocrine tumors in one bed position.
Stages of Life under Super Wide Angle
Prostate Pancer
Whole-body PET/MR scan
As can be seen from the above picture, a long AFOV PET/MR scan can give a comprehensive assessment of primary prostate cancer, pelvic LN metastases and bone metastases at the same time. Together with different MR sequences, the location, size and invasion range of the primary prostate cancer can be determined.